EFFECT OF CAFFEINE AND CODEINE ON ANTINOCICEPTIVE ACTIVITY OF ALKALOID EXTRACT FROM LEAVES OF KRATOM (MITRAGYNA SPECIOSA KORTH.)

EFFECT OF CAFFEINE AND CODEINE ON ANTINOCICEPTIVE ACTIVITY OF ALKALOID EXTRACT FROM LEAVES OF KRATOM (MITRAGYNA SPECIOSA KORTH.)
Ornchuma Botpiboon, Sathaporn Prutipanlai, Benjamas Janchawee,Sittipoom Thainchaiwattana.
Songkla University, Thailand
Regional Forensic Science Songkhla, Thailand
2007 

Abstract:
In this study, the effects of caffeine and codeine on antinociceptive activity of an alkaloid extract from leaves of M. speciosa using hot plate test were examined in rat model. The results were found that single oral administration of alkaloid extract at the dose of 100 mg/kg significantly increased latency of nociceptive response at 30, 60, 90 and 120 minutes in the heat induced pain in rats when compared with control vehicle group (p < 0.05).

Coadministration of caffeine (25 mg/kg, p.o.) or codeine (3 mg/kg, p.o.) with alkaloid extracthad no effect on the nociceptive response in rats when compared with alkaloid extract alone.35 th Congress on Science and Technology of Thailand 2 In addition, the coadminister of 3 compounds was also studied. The results showed that in alkaloid extract, caffeine and codeine treated rats significantly exhibited the increasing of latency period of antinociceptive effect only in the first 30 minutes after orally administered when compared with alkaloid extract treated group (p < 0.05). This results suggested that, caffeine and codeine administered concomitantly in subtherapeutic dose increase the antinociceptive activity of alkaloid extract only in the 30 minutes of the duration of action ofthis alkaloid extract but the effect did not occur in coadminister caffeine or codeine with alkaloid extract. This mechanism of action should be investigated further.   

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